KPV (Lys-Pro-Val), a naturally occurring tripeptide fragment derived from the C-terminal end of α-melanocyte-stimulating hormone (α-MSH). KPV is widely used in laboratory research for studying inflammatory pathways, epithelial protection, immune modulation, and cell-repair responses.
Supplied in a lyophilized powder, it is designed for in-vitro and in-vivo (animal) research models exploring mechanisms of inflammation, gut barrier function, skin barrier integrity, and cytokine regulation.
Not for human use. Research-use only.
Key Features & Specifications
Peptide: KPV (Lys-Pro-Val)
Amount: 10 mg lyophilized powder
Purity: ≥ 98–99% 
Form: Freeze-dried peptide, no fillers
Storage: ≤ -20 °C recommended; protect from moisture and light
Reconstitution: Sterile water or appropriate buffer, per laboratory protocol
Applications: Inflammatory-pathway studies, epithelial and mucosal research, cell-regeneration assays, cytokine-signaling research
Mechanism of Action (Research Context)
KPV is known for its strong anti-inflammatory and immunomodulatory properties in laboratory settings, attributed to its ability to:
1. Inhibit NF-κB Activation
NF-κB is a master regulator of inflammation.
KPV has been shown in research models to reduce NF-κB signaling, leading to decreased inflammatory pathway activation.
2. Reduce Pro-inflammatory Cytokines
Studies demonstrate decreased expression of:
TNF-α
IL-6
IL-1β
COX-2
This makes KPV a valuable tool for studying cytokine-driven inflammation.
3. Support Epithelial & Mucosal Integrity
Research indicates KPV may influence:
Tight-junction protein regulation
Barrier-function stability
Protection against epithelial stress or injury
4. Modulate Immune Responses
KPV interacts with melanocortin pathways and appears to blunt excessive immune over-activation in pre-clinical data.
Research Findings & Potential Benefits (Non-clinical Data Only)
Across various cell and animal studies, KPV has been associated with:
Reduction of inflammation in gut, skin, and epithelial models
Improved epithelial barrier function under stress conditions
Decreased inflammatory cytokine release
Diminished oxidative and inflammatory signaling
Modulation of mast cell activation and immune recruitment
Important:
These outcomes are from pre-clinical models (in vitro and animal studies).
KPV is not approved for human therapy, and effects observed in research do not establish medical use.
Research Applications
Researchers typically utilize KPV for investigations into:
Gastrointestinal inflammation models
Epithelial-cell and keratinocyte healing
Skin-barrier studies
Cytokine and immune-cell signaling
Oxidative-stress response
Mucosal integrity and repair modeling
Auto-inflammatory pathway suppression models
The peptide’s stability and short sequence make it highly versatile for mechanistic studies.
Storage & Handling (Research Protocol)
Store lyophilized vial at ≤ -20 °C.
Allow vial to reach room temperature before opening to avoid condensation.
Reconstitute with sterile water or appropriate buffer under aseptic conditions.
Aliquot into small volumes to avoid repeated freeze-thaw cycles.
Store reconstituted peptide at 2–8 °C (short term) or ≤ -20 °C (long term).
Document lot number, date of reconstitution, aliquot history, and purity data.
Summary
KPV 10 mg is a high-purity, researcher-focused peptide used for exploring immune modulation, inflammation reduction, and epithelial/mucosal protection pathways.
Its simple and stable tripeptide structure makes it a valuable tool in studies involving inflammatory cascades, barrier integrity, and cytokine regulation.
For research use only, not for human or veterinary application.