BPC-157, a 15-amino-acid peptide fragment derived from the naturally occurring Body Protection Compound (BPC) found in gastric juice. In laboratory and preclinical settings, BPC-157 is widely utilized for research involving tissue repair, angiogenesis, inflammation modulation, cell migration, and gastrointestinal mucosal protection.
The peptide is supplied as a high-purity, lyophilized powder intended exclusively for in-vitro research and animal studies.
Not for human consumption or therapeutic use.
Key Features & Specifications
Peptide: BPC-157 (Pentadecapeptide)
Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Amount: 10 mg (optional variations available)
Purity: ≥ 98–99% (HPLC/MS validated)
Appearance: White/off-white lyophilized powder
Storage: ≤ -20 °C, protected from moisture and light
Reconstitution: Sterile water or suitable buffer per research protocol
Intended Use: Mechanistic studies of repair, inflammation control, angiogenesis, and mucosal protection
Mechanism of Action (Research Context)
BPC-157 interacts with numerous cellular and molecular pathways relevant to repair and regeneration:
1. Angiogenesis & Vascular Repair
BPC-157 has been shown in cell and animal models to stimulate:
Formation of new blood vessels
Increased VEGF signaling
Improved blood flow to injured tissues
2. Gastrointestinal Mucosal Protection
Preclinical studies demonstrate:
Strengthening of the gut barrier
Protection against gastric and intestinal lining injury
Modulation of nitric oxide (NO) pathways affecting microcirculation
3. Inflammation Modulation
BPC-157 has demonstrated the ability to reduce:
NF-κB activation
Pro-inflammatory cytokines (IL-6, TNF-α)
Oxidative and inflammatory stress responses
4. Enhanced Cell Migration & Repair
Research indicates BPC-157 may promote:
Fibroblast and keratinocyte migration
Tendon, ligament, and muscle model recovery
Connective-tissue regeneration
Collagen organization and remodeling
5. Nitric Oxide (NO) System Interaction
BPC-157 appears to balance NO synthesis—both enhancing and suppressing pathways depending on the model—indicating a regulatory effect on vasodilation and tissue perfusion.
Research Findings & Potential Benefits (Pre-Clinical Evidence Only)
Across diverse in-vitro and animal research models, BPC-157 has demonstrated:
Accelerated wound healing
Improved tendon and ligament repair
Enhanced muscle regeneration
Protection of intestinal lining and GI tissues
Reduced inflammatory signaling
Improved blood vessel formation and tissue oxygenation
Protection against oxidative and chemical stressors
Note: While these findings are promising in preclinical studies, BPC-157 is not approved as a medical treatment and lacks validated human clinical trials.
Common Research Applications
Researchers investigate BPC-157 in models involving:
Tendon, ligament, and muscle injury
Skin wound repair and regeneration
Gastrointestinal inflammation & mucosal injury
Angiogenesis and vascular regeneration
Oxidative-stress and inflammation pathways
Neural & microvascular injury models
Connective tissue remodeling
These applications make BPC-157 one of the most versatile peptides in regenerative-biology research.
Storage & Handling (Research Protocol)
Storage: Keep the lyophilized peptide at ≤ -20 °C, protected from light.
Preparation: Allow vial to reach room temperature before opening to avoid condensation.
Reconstitution: Use sterile water or appropriate buffer.
Aliquoting: Divide into sterile aliquots to prevent repeated freeze-thaw cycles.
Reconstituted Storage: Short-term: 2–8 °C. Long-term: ≤ -20 °C.
Documentation: Track COA, lot number, reconstitution date, and storage conditions.
Summary
BPC-157 is a high-purity research peptide used extensively to study tissue repair, anti-inflammatory signaling, angiogenesis, and gastrointestinal protection. With strong preclinical results across multiple tissue types, it remains a leading peptide in regenerative research fields.
For research use only. Not for human or veterinary use.